Sickle Cell Disease: Expert emphasise use of HPLC for genotype test
Dr. Emeka Nwakamma, the Chief Medical Director of a health foundation in Umuahia, has urged the government to ensure the use of high-performance liquid chromatography (HPLC) for genotype testing to reduce recurring cases of sickle cell disease (SCD).
He made the call in an interview with the newsmen in Umuahia on Monday.
Supreme News reports that HPLC, formerly referred to as high-pressure liquid chromatography, is a technique in analytical chemistry used to separate, identify, and quantify specific components in mixtures.
Hb HPLC is essential for diagnosing SCD, thalassemia and rare hemoglobin disorders.
Nwakamma, who said he had been treating SCD patients, regretted that “even in these contemporary times, false laboratory test results are aiding marriages that produce SCD children.
“That is why our foundation insists on the use of HPLC genotype tests before marriage.
“This equipment is available and should be in every government hospital laboratory.
“HPLC is sensitive and specific, has an advantage over electrophoresis for quantifying Hb F and Hb A2, and can detect other variants in a single screening test.
“However, the HPLC test is expensive, which is why we are urging the government to come in and subsidise.’’
Nwakamma, who is also the Medical Director of Nkechi Medical Centre, Ohanze Obingwa, said, “SCD is becoming endemic in Nigeria; it needs extra effort from the government to checkmate it.’’
He urged the government to implement the Blood Group and Genotype Law, which ensures all individuals have their blood group and genotype on their identification card (ID) cards.
“This will be a quick pointer to genotype incompatibility prior to marriage and procreation,’’ he added.
He explained that the greatest challenges associated with SCD are the huge financial and emotional costs, leading families to use up their savings for medical expenses.
He suggested that “the government should, as a matter of urgency, formulate a healthcare insurance model that reduces the cost of care for people with the disease.
“Government should stop discrimination and stigmatisation of people with SCD in the workplace due to recurrent illnesses and ensure they don’t lose jobs because of frequent hospital stays.’’
